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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Neural Comput. 2015 Mar 3;27(4):898–924. doi: 10.1162/NECO_a_00712

Figure 5.

Figure 5

Ca2+ wave propagation is sensitive to density of IP3Rand SERCA. 2838 simulations varying IP3R (86 levels) and SERCA density (33 levels) relative to baseline shows different dynamics: region 1: sustained Ca2+ elevation precluded IP3-evoked wave; region 2: multiple Ca2+ waves; region 3: single Ca2+ wave; region 4: insufficient IP3R to source Ca2+ wave. (a) time to Ca2+ wave onset where present, (b) speed where wave present, (c) duration where wave present (median duration of Ca2+ elevation across dendritic locations), (d) maximum calcium level.