Table 3.
Pharmacokinetic parameters of the two formulations
| Parameter | Formulations
|
|
|---|---|---|
| PLD-HPMC | PLD-loaded liposome | |
| t1/2 (hours) | 2.78±0.89 | 18.36±3.54* |
| Cmax (ng/mL) | 1,562.7±453.2 | 1,898.3±376.5 |
| AUC0–t (ng·hour/mL) | 4,399.3±476.9 | 13,516.1±876.4* |
| AUC0–∞ (ng·hour/mL) | 5,387.4±527.4 | 15,241.5±945.5* |
| MRT (hours) | 6.8±2.3 | 32.2±3.4* |
| V (L/kg) | 122.5±10.1 | 28.6±2.7* |
| CL (L/hour/kg) | 15.7±2.2 | 7.9±1.7* |
Note:
*
P<0.05: PLD-HPMC versus PLD-loaded liposome.
Abbreviations: AUC, area under the concentration-time curve; HPMC, hydroxypropyl methyl cellulose; MRT, mean residence time; PLD, polydatin; t1/2, half-life period; Cmax, concentration maximum; V, apparent volume of distribution; CL, clearance.