Figure 3.
Neurotransmitters and their hypothetically malfunctioning brain circuits in regions associated with the diagnostic symptoms for depression.
Notes: Depression diagnosis requires at least one of these *symptoms and ≥4 of these †symptoms. From Lum CT, Stahl SM. Opportunities for reversible inhibitors of mono amine oxidase-A (RIMAs) in the treatment of depression. CNS Spectrums. 2012;17(3):107–120, reproduced with permission.60
Abbreviations: A, amygdala; BF, basal forebrain; C, cerebellum; H, hypothalamus; NA, nucleus accumbens; NT, neurotransmitter centers; PFC, prefrontal cortex; S, striatum; SC, spinal cord; T, thalamus.