Table 2.
Possible pharmacotherapeutic approaches for the treatment of select symptoms in MDD
| Symptom | Pharmacotherapy |
|---|---|
| Anxiety* | • Buspirone |
| • Citalopram | |
| • Escitalopram | |
| •Fluoxetine | |
| • Fluvoxamine | |
| • Lorazepam | |
| • Mirtazapine | |
| • Sertraline | |
| • Venlafaxine | |
| • Vilazodone | |
| • Vortioxetine | |
| • Doxepin | |
| Cognitive problems | • Donepezil |
| • Duloxetine | |
| • Galantamine | |
| • Methylphenidate | |
| • Modafinil | |
| • Vortioxetine | |
| Insomnia | • Amitriptyline |
| • Eszopiclone | |
| • Doxepin | |
| • Maprotiline | |
| • Mirtazapine | |
| • Nefazodone | |
| • Nortriptyline | |
| • Paroxetine | |
| • Ramelteon | |
| • Trazodone | |
| • Zaleplon | |
| • Zolpidem | |
| Lack of energy/fatigue | • Atomoxetine |
| • Bupropion | |
| • Desvenlafaxine | |
| • Fluoxetine | |
| • Modafinil | |
| • Sertraline | |
| • Venlafaxine | |
| Pain | • Amitriptyline |
| • Doxepin | |
| • Duloxetine | |
| • Milnacipran | |
| • Nortriptyline | |
| • Venlafaxine | |
| Psychomotor problems | • Ziprasidone |
| • Venlafaxine | |
| Poor appetite/weight loss | • Mirtazapine |
| Sleepiness | • Atomoxetine |
| • Bupropion | |
| • Modafinil |
Note:
*
Most SSRIs are also approved by the US Food and Drug Administration to treat generalized anxiety disorder.
Abbreviations: MDD, major depressive disorder; SSRI, selective serotonin reuptake inhibitor.