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. 2015 Apr 6;10(4):e0123047. doi: 10.1371/journal.pone.0123047

Table 2. GO:C5 MS5-upregulated mRNA pathways.

Gene Set Description P # Up # Down
Cellular Component (none met criterion P<0.01)
Molecular Function
3',5'-cAMP Phosphodiesterase Activity 0.003 11 2
Cyclic Nucleotide Phosphodiesterase Activity 0.004 12 2
N-methyltransferase Activity 0.001 8 5
Oxidoreductase Activity 0.008 18 12
Phosphatase Inhibitor Activity 0.001 10 1
Phosphatase Regulator Activity 0.009 19 6
Serotonin Receptor Activity 0.001 7 3
SH2 Domain Binding 0.005 11 4
Sodium Channel Activity 0.008 10 5
Transcription Elongation Regulator Activity 0.009 7 3
Biological Process
B Cell Activation 0.008 11 8
Behavior 0.003 76 57
Calcium-mediated Signaling 0.003 11 4
cAMP-Mediated Signaling 0.004 40 23
Cell Activation 0.007 38 30
Central Nervous System Development 0.0002 64 53
Chromosome Organization and Biogenesis 0.003 7 3
Endothelial Cell Proliferation 0.0001 7 3
G Protein Receptor Pathway 0.0004 175 142
Hormone Secretion 0.002 12 4
Leukocyte Differentiation 0.010 21 14
Lymphocyte Activation 0.010 13 7
Multicellular Organismal Process 0.0002 76 62
Muscle Contraction 0.0001 13 5
Myeloid Cell Differentiation 0.005 11 6
Negative Regulation of Catalytic Activity 0.003 37 28
Neurological System Process 0.004 201 152
Positive Regulation of Cell Adhesion 0.001 8 3
Regulation of Homeostasis 0.003 8 4
Response to Extracellular Stimulus 0.007 18 14
Second Messenger-mediated Signaling 0.001 85 61

Gene sets (GO:C5) with mRNAs exhibiting upregulated expression due to neonatal morphine (MS5) exposure. Alphabetical order.