Table 7. Hippocampal miR and miR-targeted mRNA expression was altered in neonatal mice exposed to stress plus morphine (MS5) compared to control.
miR | Fold change log2 | P miR | Targeted mRNA | Fold change log2 | P mRNA | mRNA product |
---|---|---|---|---|---|---|
204-5p | -1.222 | 0.049 | Ap1s2 | -0.764 | 0.002 | adaptor complex 1 σ2 a |
Syt6 | 0.97 | 0.047 | synaptotagmin VI a | |||
448-5p | Acox2 | -0.927 | 0.011 | acyl-CoA oxidase 2 b | ||
Kl | -1.108 | 0.006 | klotho b | |||
-1.589 | 0.024 | Otx2 | -1.257 | 0.031 | orthodenticle homeobox 2 c | |
Prdm16 | -0.601 | 0.023 | PR domain containing 16 c | |||
Sema3A | 0.599 | 0.043 | semaphorin domain 3A d | |||
455-5p | Ap1s2 | -0.764 | 0.002 | adaptor complex 1 σ2 a | ||
-0.695 | 0.004 | Pdzd2 | 0.596 | 0.049 | PDZ domain 2 e | |
Prg4 | 0.798 | 0.014 | proteoglycan 4 f |
All targets are either high or moderate predicted in IPA. protein categories
a transporter protein
b enzyme
c transcription regulator
d immunoglobulin
e neurotransmission
f proteoglyclan. Alphabetical order.