Table 2.
| Elevated Inflammatory Markers in CSF of Specific Patient Groups | Elevated
Inflammatory Markers in Serum of Specific Patient Groups |
||||||
|---|---|---|---|---|---|---|---|
| All Patients | All patients except MPS-IS and Sanfilippo syndrome type A |
All patients except MPS-IS |
Only elevated
in: Infantile gangliosidosis and Late-infantile GM1- gangliosidosis |
Only elevated
in: Infantile gangliosidosis |
Mixed
results across patient groups |
All patients | Infantile GM1 gangliosidosis |
| Heparin-Binding EGF-Like Growth Factor (HB-EGF) | Alpha-1-Antichymotrypsin (AACT) | Hepatocyte Growth Factor (HGF) | Macrophage Migration Inhibitory Factor (MIF) | Epithelial-Derived Neutrophil-Activating Protein 78 (ENA-78) | Apolipoprotein A-I (Apo A-I) | Osteopontin | Insulin-like Growth Factor-Binding Protein 2 (IGFBP-2) |
| Tamm-Horsfall Urinary Glycoprotein (THP) | Sex Hormone-Binding Globulin (SHBG) | Matrix Metalloproteinase-3 (MMP-3) | Monocyte Chemotactic Protein 1 (MCP-1) | ||||
| Macrophage Inflammatory Protein-1 alpha (MIP-1 alpha) | |||||||
| Macrophage Inflammatory Protein-1 beta (MIP-1 beta) | |||||||
| Tumor Necrosis Factor Receptor 2 (TNFR2) | |||||||
| Inflammatory Markers Not Elevated in CSF or Serum | |||||||
| Alpha-1-Microglobulin (A1Micro) | Apolipoprotein C-I (Apo C-I) | Cystatin-C | Immunoglobulin M (IGM) | Placenta Growth Factor (PLGF) | Tumor Necrosis Factor alpha (TNF-alpha) | ||
| Alpha-2-Macroglobulin (A2Macro) | Apolipoprotein C-III (Apo C-III) | Epidermal Growth Factor Receptor (EGFR) | Interleukin-6 receptor (IL-6r) | T-Cell-Specific Protein RANTES (RANTES) | Serotransferrin (Transferrin) | ||
| Alpha-1-Antitrypsin (AAT) | Apolipoprotein D (Apo D) | EN-RAGE | Interleukin-8 (IL-8) | Resistin | Thyroid-Stimulating Hormone (TSH) | ||
| Angiotensin-Converting Enzyme (ACE) | Apolipoprotein E (Apo E) | Fetuin-A | Interferon gamma Induced Protein 10 (IP-10) | S100 calcium-binding protein B (S100-B) | Vascular Cell Adhesion Molecule-1 (VCAM-1) | ||
| Adiponectin | Apolipoprotein H (Apo H) | Ferritin (FRTN) | Leptin | Serum Amyloid P-Component (SAP) | Vitronectin | ||
| Alpha-Fetoprotein (AFP) | Beta-2-Microglobulin (B2M) | Follicle-Stimulating Hormone (FSH) | Lectin-Like Oxidized LDL Receptor 1 (LOX-1) | Stem Cell Factor (SCF) | von Willebrand Factor (vWF) | ||
| Angiopoietin-2 (ANG-2) | Complement C3 (C3) | Growth Hormone (GH) | Monokine Induced by Gamma Interferon (MIG) | Superoxide Dismutase 1, Soluble (SOD-1) | |||
| Apolipoprotein A-II (Apo A-II) | CD5 (CD5L) | Haptoglobin | Neuronal Cell Adhesion Molecule (Nr-CAM) | Thyroxine-Binding Globulin (TBG) | |||
| Apolipoprotein A-IV (Apo A-IV) | Complement Factor H – Related Protein 1 (CFHR1) | Intercellular Adhesion Molecule 1 (ICAM-1) | N-terminal prohormone of brain natriuretic peptide (NT roBNP) | Trefoil Factor 3 (TFF3) | |||
| Apolipoprotein B (Apo B) | C-Reactive Protein (CRP) | Immunoglobulin A (IgA) | Plasminogen Activator Inhibitor 1 (PAI-1) | Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) | |||