Table 3.
Incidence of Grade 3–4 Cytopenia During Dasatinib Therapy by Dasatinib Dose and Daily Schedule*
| Type of Cytopenia, No. (%) | |||
|---|---|---|---|
| Total (n=67) | Grade 3–4 Neutropenia |
Grade 3–4 Thrombocytopenia |
Grade 3–4 Anemia |
| Dasatinib daily dose | |||
| >140 mg/d | 2 (3) | 3 (4) | 0 (0) |
| 140 mg/d | 22 (33) | 20 (30) | 5 (7) |
| 100 mg/d | 19 (28) | 13 (19) | 5 (7) |
| <100 mg/d | 7 (10) | 5 (7) | 5 (7) |
| Schedule | |||
| Once daily | 23 (34) | 17 (25) | 7 (10) |
| Twice daily | 27 (40) | 24 (36) | 8 (12) |
*
Toxicities were graded according to the National Cancer Institute Common Terminology Criteria (version 3.0).