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. Author manuscript; available in PMC: 2015 Apr 6.
Published in final edited form as: Nat Rev Nephrol. 2014 May 27;10(7):379–388. doi: 10.1038/nrneph.2014.87

Figure 1.

Figure 1

Lipids in the slit diaphragm. Slit-diaphragm proteins such as podocin contain prohibitin-domains that enable binding to cholesterol and the formation of multiprotein complexes such as that between podocin and TrpC6. Lipid raft domains in podocytes contain cell-specific gangliosides such as GD3. Other slit-diaphragm proteins such as nephrin and CD2-associated protein are bound to caveolin-1, a protein specific to lipid rafts. Antibodies against GD3 can increase nephrin phosphorylation and its trafficking from the plasma membrane to the cytosol. Lipids are shown in different shades of orange. Abbreviations: GD3, disialosyllactosylceramide; TrpC6, short transient receptor potential cation channel 6.