Table 2.

Results of quality review. All numbers represent the number of articles that matches corresponding criterion in Table 1

	Carbamazepine [8,19,40–49]	Ethosuximide [41,45,50–54]	Phenobarbital [20,41,55–58]	Phenytoin [20,41,45,59–64]	Lamotrigine [10,16,18,65–72]	Valproic acid [45,73–79]	Pregabalin [80]	Clonazepam [9,63]	Gabapentin [17,81,82]	Levetiracetam [83–86]	Oxcarbazepine [87–89]	Primidon [41,42,45,58,90]	Topiramate [91–93]	Vigabatrine [21]
Number of studies included	12	7	6	9	11	8	1	2	3	4	3	5	3	1
Publication status
Abstract	2	2	0	0	4	0	1	0	1	2	1	0	1	0
Case report/letter	5	1	1	2	3	3	0	2	1	0	1	2	0	0
Full article	5	4	5	7	4	5	0	0	1	2	1	3	2	1
Study design
Median number of patients (min−max)	3 (1–56)	2 (1–5)	8 (1–13)	3 (1–9)	6 (1–34)	4 (1–13)	2 (2–2)	1 (1–1)	3 (1–5)	12.5 (7–14)	1 (1–3)	7 (1–12)	1 (1–3)	2 (2–2)
Longitudinal design	7	3	3	4	3	5	0	2	0	2	2	3	1	0
Amount of drug in breast milk
Daily dose	10	5	2	7	7	8	0	1	2	3	2	3	3	1
Time of drug intake until sampling	1	2	4	6	5	4	0	1	1	2	2	0	1	1
Representative milk samples	2	1	0	2	2	0	0	1	1	0	0	1	1	1
Determination of kinetics
Milk concentrations	0	0	0	1	2	0	0	0	1	0	0	0	0	0
Plasma concentrations	0	0	0	0	1	0	0	0	0	0	0	0	0	0
Active metabolites	5	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	2	N/A	N/A	N/A
Infant plasma	7	3	3	5	9	5	1	2	3	3	3	2	1	0
Endpoints
M : P correctly assessed	0	0	0	0	1	0	0	0	1	0	0	0	0	0
AID correctly assessed	1	0	0	1	2	0	0	0	1	0	0	0	0	1

Values in bold correspond to endpoints.

AID, Absolute infant dose; M : P, Milk : plasma ratio; N/A, Not applicable.