Figure 2.
Concentration ratios of amniotic fluid : maternal plasma related to the isomers of metoprolol (MET), α-hydroxymetoprolol (OHM) and O-desmethylmetoproloic acid (AODM) as a function of time between metoprolol administration and sample collection in hypertensive parturients (control group; n = 11) treated with a single oral dose of 100 mg racemic metoprolol tartrate. Each point on the curve corresponds to the sample from one patient. 
, R-(+)-MET; 
, S-(–)-MET; 
, 1′S,2R-OHM; 
, 1′S,2S-OHM; 
, 1′R,2R-OHM; 
, 1′R,2S-OHM; 
, R-(+)-AODM; 
, S-(–)-AODM