Table 4.
Ratios of the umbilical cord : maternal plasma and amniotic fluid : maternal plasma concentrations of the metoprolol (MET), α-hydroxymetoprolol (OHM) and O-desmethylmetoproloic acid (AODM) isomers in the parturients of the control and diabetic groups (median and 95% CI)
| Isomer | Umbilical cord/maternal plasma | Amniotic fluid/maternal plasma | ||
|---|---|---|---|---|
| Control group (n = 22) | Diabetes group (n = 10) | Control group (n = 13) | Diabetes group (n = 5) | |
| R-(+)-MET | 1.04 (0.91, 1.70) | 1.06 (0.63, 1.42) | 2.99 (2.09, 6.89) | 0.40 (0.01, 2.18) |
| S-(–)-MET | 1.15 (1.06, 1.41) | 1.08 (0.64, 1.32) | 3.23 (2.27, 6.96) | 0.51 (0.39, 2.12) |
| 1′S,2R-OHM | 1.10 (1.01, 1.51) | 1.06 (0.63, 1.42) | 5.06 (2.28, 10.02) | 0.44 (0.03, 0.99) |
| 1′S,2S-OHM | 1.09 (1.00, 1.39) | 0.79* (0.42, 1.06) | 3.95 (1.74, 9.58) | 0.39 (0.072, 0.66) |
| 1′R,2R-OHM | 0.95 (0.83, 1.28) | 0.73* (0.39, 1.01) | 1.63 (0.34, 11.90) | 0.20 (0.01, 3.76) |
| 1′R,2S-OHM | 0.92 (0.83, 1.28) | 0.66* (0.38, 1.03) | 1.45 (0.24, 9.28) | 0.29 (0.01, 3.36) |
| S-(-)-AODM | 0.83 (0.70, 0.94) | 0.65 (0.51, 0.76) | 0.83 (0.67, 0.92) | 0.63 (0.45, 0.73) |
| R-(+)-AODM | 0.29 (0.02, 2.50) | 0.13 (0.01, 0.44) | 0.37 (0.05, 3.22) | 0.12 (0.10, 0.61) |
Kruskal–Wallis test for paired data, P < 0.05: #1′S.2R vs. 1′R.2R; ♣1′S.2S vs. 1′R.2R; ♦1′S.2R vs. 1′R.2S; ⊗1′S.2S vs. 1′R.2S. ▪Wilcoxon test for paired data, P < 0.05 (R-(+) vs. S-(–)).
*
Mann–Whitney test, P < 0.05 (Control group vs. diabetes group).