Table 2.
Pharmacokinetic parameters of metformin in Indigenous and non-Indigenous patients
| Parameter | Indigenous | Non-Indigenous |
|---|---|---|
| n | 50 | 120 |
| CL/F (l h−1) | 54 (42–77) | 46 (31–64)* |
| Ratio of CL/F to CLCR | 13.1 (10.2–14.9) | 12.6 (9.9–14.9) |
| V1/F (l) | 221 (177–278) | 206 (167–248) |
| Ratio of V1/F to bodyweight | 2.5 (2.2–3.2) | 2.4 (2.1–2.9) |
Values are presented as the median and interquartile range. Abbreviations are as follows: CL/F, apparent clearance of metformin; CLCR, creatinine clearance; V1/F, apparent volume of the central compartment.
*
P < 0.05.