Table 3.

Comparison of pharmacokinetic parameters following a single subcutaneous dose of PEG-IFN-SA (1.5 μg kg⁻¹) and Pegasys (180 μg) in healthy volunteers

Parameter	PEG-IFN-SA (n = 8)	Pegasys (n = 5)
	Geometric mean (%CV)	Geometric mean (%CV)
AUC(0–168h) (μg l−1 h)	44.0 (47.2)	1103.1 (75.8)
Cmax (μg l−1)	0.53 (57.7)	12.3 (61.9)
Tmax (h)*	26.9 (16, 60)	90.7 (34, 168)
t1/2 (h)*	55.3 (22.3, 113.2)	–

Abbreviations are as follows: AUC_(0–168h), area under the plasma concentration–time curve from time of dosing to168 h; C_max, maximal observed concentration; CV, coefficient of variation; T_max, time to reach C_max.

^*Values are given as the median (range).