Figure 2.
Effect of the monoamine uptake blockers on vagally evoked release of 5-HT in the NTS
Experimental traces showing the effects of citalopram (1 mg kg−1, i.v.; A), desipramine (1 mg kg−1; B) and decynium-22 (D-22; 600 μg kg−1; C) on the 5-HT signal and the decreases in blood pressure (BP) and heart rate (HR) evoked by electrical stimulation (20 Hz, 1 ms, 10 s at 10 times threshold) of the central end of the left vagus. D shows bar graphs of the combined data comparing the effects of vehicle (DMSO, 0.1 ml kg−1; n = 6), citalopram (CIT; n = 6), D-22 (n = 6); desipramine (DES; n = 6) and WAY-100635 (WAY; 1 mg kg−1; n = 4). Also shown is WAY-100635 given 3 min after citalopram (CIT + WAY; n = 5). The error bars show the SEM. These changes were compared with control values using a one-way ANOVA and the means compared with Fisher's LSD test. *P < 0.05, **P < 0.01 and ***P < 0.001.