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. 2015 Feb 19;593(Pt 7):1715–1729. doi: 10.1113/jphysiol.2014.285312

Figure 3.

Figure 3

The effect of activation of the cardiovascular reflexes on 5-HT release in the NTS

The effect of activation of the cardiovascular reflexes on 5-HT release in the NTS Traces showing the effects of activation of the cardiopulmonary reflex with intra-atrial (i.a.) phenylbiguanide (PBG; 30 μg in 10 μl; A), the chemoreflex with i.v. NaCN (200 μg in 10 μl; B), the depressor reflex with i.v. noradrenaline (NA; 50 μg; C) and the pressor reflex with i.v. sodium nitroprusside (SNP; D) on the 5-HT signal, blood pressure (BP) and heart rate (HR). Histograms of the combined data (n = 4 or 5) for each reflex using different levels of activation of these receptors are shown below each trace. Doses of reflex activators were randomized between experiments. The error bars show the SEM. Changes were compared with the baseline (BL) values obtained before the first reflex evoked by the above substances using a one-way ANOVA and the means compared with Fisher's LSD test. *P < 0.05 and ***P < 0.001.