Figure 5.

Effects of topical application of kynurenate (KYN) to the NTS on vagally evoked release of 5-HT

On the left are traces showing the effect of application of 10 (A) and 50 mm KYN (B) on changes in the 5-HT signal, heart rate (HR) and blood pressure (BP) evoked by electrical stimulation (20 Hz, 1 ms, 3 s at 10 times threshold) of the central end of the left vagus. C shows histograms of the combined data on the these effects. The error bars show the SEM. These changes caused by kynurenate [10 (n = 6) and 50 mm (n = 7)] were compared with control (PBS; 0.01 m; n = 5) using a one-way ANOVA and the means compared with Fisher's LSD test. ***P < 0.001.