Table 1.

Pharmacological adjunctive conditioning therapy in myocardial infarction

	Intervention	N	Clinical scenario	Outcome
Adenosine
Mahaffey et al. (1999) (AMISTAD)	Infusion of adenosine for 3 h	236	STEMI – thrombolysis	Reduction in infarct size
Kloner et al. (2006) (AMISTAD II)	Infusion of adenosine for 3 h	2118	STEMI – thrombolysis or primary PCI	No difference in death or HF
Atorvastatin
Kim et al. (2010) (STATIN-STEMI)	Oral atorvastatin 80 mg before primary PCI	171	STEMI – primary PCI	No difference in death, revascularization or infarct size
Hahn et al. (2011b)	Oral atorvastatin 80 mg before primary PCI	173	STEMI – primary PCI	No difference in infarct size
Cyclosporin A
Piot et al. (2008)	Cyclosporin infusion before primary PCI	58	STEMI – primary PCI	Reduction in infarct size
Erythropoietin
Voors et al. (2010)	Single dose EPO	529	STEMI – primary PCI	No difference in LVEF or infarct size
Exenatide
Lonborg et al. (2012b)	Infusion of exenatide for 6 h	107	STEMI – primary PCI	Reduction in infarct size
Glucose-insulin-potassium (GIK)
Mehta et al. (2005) (CREATE-ECLA)	Infusion of GIK for 24 h	20 201	STEMI – thrombolysis	No difference in mortality
Selker et al. (2012) (IMMEDIATE)	Out-of-hospital infusion of GIK	357	STEMI – thrombolysis	Reduced mortality among patients with cardiac arrest
PKC-δ inhibitor
Bates et al. (2008)	2 doses of KAI 9803	154	STEMI – primary PCI	No difference in infarct size

HF, heart failure; LVEF, left ventricular ejection fraction.