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. 2015 Feb 10;172(8):2148–2164. doi: 10.1111/bph.13039

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Copyright © 2015 The British Pharmacological Society

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Antinociceptive profiles of oxycodone (Oxy) and morphine (Mor) against mechanical hypersensitivity in the FBC model. The antinociceptive effects of Oxy, but not those of Mor, were abolished by the K_ir3.1 channel inhibitor tertiapin-Q (Ter-Q). Each column represents means ± SEM (n = 9–13). A comparison of all groups was performed using a Kruskal–Wallis test and Dunn's multiple-comparison test. In this graph, the antinociceptive effects of Oxy and Mor were followed by asterisks indicating a statistically significant difference between saline (Sal)-treated groups and the Oxy with Sal-treated groups or the Mor with Sal-treated groups; **P < 0.01. The distinct sensitivity to K_ir3.1 channel inhibition of the antinociceptive effects of Oxy and Mor were followed by the asterisk indicating the difference betweenOxy with Sal-treated groups and Oxy with trertiapin-Q treated groups; *P < 0.05. No significance (n.s.) indicates a no statistically significant difference between the Mor with Sal-treated groups and the morphine with trertiapin-Q treated group.