Table 3.
Summary of genetic and common environmental contribution estimates at single data points for each tract.
| No. of data points | FA
|
AD
|
RD
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| a2, mean [range] | % of significant points of a2 | c2, mean [range] | a2, mean [range] | % of significant points of a2 | c2, mean [range] | a2, mean [range] | % of significant points of a2 | c2, mean [range] | ||
| Corpus callosum | ||||||||||
| rostrum, orbitofrontal | 95 | 0.24 [0–0.46] | 45.3 | 0.03 [0–0.19] | 0.07 [0–0.59] | 16.8 | 0.21 [0–0.39] | 0.32 [0–0.52] | 74.7 | 0.05 [0–0.27] |
| genu, prefrontal | 94 | 0.25 [0–0.58] | 66.0 | 0.07 [0–0.33] | 0.14 [0–0.50] | 38.3 | 0.22 [0–0.41] | 0.31 [0–0.54] | 79.8 | 0.09 [0–0.34] |
| body, premotor | 92 | 0.33 [0–0.71] | 73.9 | 0.02 [0–0.14] | 0.19 [0–0.57] | 39.1 | 0.21 [0–0.39] | 0.37 [0–0.69] | 81.5 | 0.08 [0–0.40] |
| body, motor | 87 | 0.35 [0–0.58] | 67.8 | 0.03 [0–0.21] | 0.14 [0–0.62] | 31.0 | 0.18 [0–0.36] | 0.33 [0–0.64] | 70.1 | 0.06 [0–0.28] |
| body, parietal | 128 | 0.28 [0–0.63] | 64.8 | 0.06 [0–0.24] | 0.10 [0–0.54] | 17.2 | 0.20 [0–0.37] | 0.30 [0–0.54] | 73.4 | 0.06 [0–0.33] |
| splenium, occipital | 152 | 0.39 [0–0.70] | 71.7 | 0.05 [0–0.24] | 0.10 [0–0.50] | 16.4 | 0.16 [0–0.31] | 0.31 [0–0.55] | 67.1 | 0.09 [0–0.36] |
| tapetum, temporal | 181 | 0.31 [0–0.54] | 66.3 | 0.05 [0–0.33] | 0.19 [0–0.64] | 29.8 | 0.18 [0–0.45] | 0.26 [0–0.64] | 50.8 | 0.10 [0–0.33] |
| Corticothalamic tract | ||||||||||
| prefrontal, left | 81 | 0.29 [0–0.52] | 63.0 | 0.02 [0. –0.26] | 0.13 [0–0.47] | 46.9 | 0.20 [0–0.27] | 0.18 [0–0.52] | 48.1 | 0.10 [0–0.28] |
| prefrontal, right | 79 | 0.23 [0–0.40] | 55.7 | 0.04 [0–0.31] | 0.14 [0–0.50] | 50.6 | 0.21 [0–0.45] | 0.15 [0–0.50] | 43.0 | 0.16 [0–0.31] |
| premotor, left | 79 | 0.25 [0–0.53] | 50.6 | 0.03 [0–0.26] | 0.10 [0–0.58] | 26.6 | 0.20 [0–0.41] | 0.23 [0–0.50] | 62.0 | 0.08 [0–0.22] |
| premotor, right | 80 | 0.23 [0–0.46] | 40.0 | 0.09 [0–0.33] | 0.13 [0–0.53] | 50.0 | 0.23 [0–0.43] | 0.22 [0–0.48] | 61.3 | 0.13 [0–0.29] |
| motor, left | 80 | 0.16 [0–0.44] | 28.8 | 0.11 [0–0.32] | 0.15 [0–0.59] | 53.8 | 0.17 [0–0.37] | 0.22 [0–0.52] | 57.5 | 0.09 [0–0.26] |
| motor, right | 82 | 0.23 [0–0.55] | 50.0 | 0.08 [0–0.29] | 0.14 [0–0.64] | 51.2 | 0.21 [0–0.46] | 0.24 [0–0.52] | 59.8 | 0.11 [0–0.27] |
| parietal, left | 68 | 0.23 [0–0.43] | 45.6 | 0.07 [0–0.26] | 0.07 [0–0.55] | 35.3 | 0.23 [0–0.41] | 0.18 [0–0.49] | 50.0 | 0.13 [0–0.28] |
| parietal, right | 64 | 0.31 [0–0.58] | 62.5 | 0.04 [0–0.23] | 0.13 [0–0.67] | 48.4 | 0.23 [0–0.46] | 0.24 [0–0.49] | 65.6 | 0.10 [0–0.25] |
| Corticofugal tract | ||||||||||
| prefrontal, left | 109 | 0.24 [0–0.41] | 54.1 | 0.04 [0–0.26] | 0.06 [0–0.40] | 27.5 | 0.25 [0–0.45] | 0.12 [0–0.42] | 36.7 | 0.15 [0–0.33] |
| prefrontal, right | 110 | 0.18 [0–0.36] | 32.7 | 0.07 [0–0.26] | 0.09 [0–0.48] | 35.5 | 0.22 [0–0.59] | 0.11 [0–0.44] | 35.5 | 0.17 [0–0.32] |
| premotor, left | 112 | 0.20 [0–0.52] | 40.2 | 0.07 [0–0.30] | 0.09 [0–0.58] | 28.6 | 0.24 [0–0.43] | 0.16 [0–0.50] | 49.1 | 0.13 [0–0.30] |
| premotor, right | 117 | 0.23 [0–0.46] | 39.3 | 0.06 [0–0.29] | 0.33 [0–0.61] | 53.0 | 0.08 [0–0.33] | 0.22 [0–0.48] | 59.0 | 0.09 [0–0.24] |
| motor, left | 121 | 0.21 [0–0.53] | 46.3 | 0.09 [0–0.34] | 0.12 [0–0.62] | 48.8 | 0.20 [0–0.42] | 0.18 [0–0.55] | 45.5 | 0.12 [0–0.27] |
| motor, right | 122 | 0.23 [0–0.61] | 45.9 | 0.08 [0–0.36] | 0.09 [0–0.56] | 31.1 | 0.23 [0–0.47] | 0.18 [0–0.54] | 41.0 | 0.11 [0–0.33] |
| parietal, left | 120 | 0.22 [0–0.54] | 48.3 | 0.07 [0–0.31] | 0.06 [0–0.34] | 27.5 | 0.21 [0–0.40] | 0.15 [0–0.44] | 41.7 | 0.10 [0–0.26] |
| parietal, right | 119 | 0.24 [0–0.72] | 40.3 | 0.07 [0–0.29] | 0.11 [0–0.58] | 39.5 | 0.19 [0–0.50] | 0.14 [0–0.53] | 29.4 | 0.11 [0–0.33] |
| Medial lemniscal pathway | ||||||||||
| Left | 42 | 0.14 [0–0.45] | 16.7 | 0.08 [0–0.27] | 0.12 [0–0.37] | 16.7 | 0.13 [0–0.33] | 0.14 [0–0.30] | 14.3 | 0.10 [0–0.28] |
| Right | 42 | 0.10 [0–0.36] | 9.5 | 0.08 [0–0.30] | 0.12 [0–0.43] | 0.0 | 0.14 [0–0.28] | 0.09 [0–0.43] | 0.0 | 0.18 [0–0.33] |
| Cingulum | ||||||||||
| cingulate gyrus, left | 86 | 0.20 [0–0.39] | 16.3 | 0.06 [0–0.25] | 0.12 [0–0.46] | 14.0 | 0.10 [0–0.40] | 0.15 [0–0.36] | 31.4 | 0.08 [0–0.26] |
| cingulate gyrus, right | 79 | 0.10 [0–0.32] | 0.0 | 0.09 [0–0.26] | 0.12 [0–0.41] | 19.0 | 0.13 [0–0.35] | 0.18 [0–0.42] | 35.4 | 0.08 [0–0.25] |
| hippocampal, left | 104 | 0.32 [0–0.60] | 42.3 | 0.06 [0–0.35] | 0.02 [0–0.32] | 2.9 | 0.21 [0–0.32] | 0.13 [0–0.53] | 31.7 | 0.16 [0–0.36] |
| hippocampal, right | 102 | 0.37 [0–0.59] | 61.8 | 0.05 [0–0.30] | 0.03 [0–0.31] | 2.9 | 0.17 [0–0.41] | 0.13 [0–0.49] | 25.5 | 0.14 [0–0.30] |
| Fornix | ||||||||||
| Left | 142 | 0.30 [0–0.52] | 62.0 | 0.08 [0–0.50] | 0.20 [0–0.61] | 37.3 | 0.18 [0–0.42] | 0.24 [0–0.62] | 47.9 | 0.14 [0–0.36] |
| Right | 146 | 0.37 [0–0.66] | 64.4 | 0.05 [0–0.37] | 0.42 [0–0.81] | 62.3 | 0.08 [0–0.38] | 0.46 [0–0.85] | 67.1 | 0.05 [0–0.34] |
| Arcuate fasciculus | ||||||||||
| fronto-parietal, left | 70 | 0.28 [0–0.51] | 51.4 | 0.03 [0–0.32] | 0.05 [0–0.43] | 7.1 | 0.21 [0–0.37] | 0.27 [0–0.44] | 74.3 | 0.11 [0–0.30] |
| fronto-parietal, right | 61 | 0.31 [0–0.48] | 59.0 | 0.03 [0–0.28] | 0.17 [0–0.54] | 36.1 | 0.17 [0–0.39] | 0.38 [0–0.53] | 91.8 | 0.06 [0–0.21] |
| fronto-temporal, left | 117 | 0.15 [0–0.46] | 23.9 | 0.14 [0–0.30] | 0.07 [0–0.32] | 4.3 | 0.17 [0–0.40] | 0.24 [0–0.47] | 59.8 | 0.08 [0–0.21] |
| fronto-temporal, right | 106 | 0.25 [0–0.54] | 39.6 | 0.05 [0–0.24] | 0.05 [0–0.48] | 11.3 | 0.24 [0–0.40] | 0.25 [0–0.50] | 70.8 | 0.13 [0–0.28] |
| temporo-parietal, left | 79 | 0.10 [0–0.38] | 8.9 | 0.10 [0–0.32] | 0.10 [0–0.48] | 12.7 | 0.13 [0–0.36] | 0.17 [0–0.49] | 45.6 | 0.10 [0–0.28] |
| temporo-parietal, right | 76 | 0.19 [0–0.40] | 36.8 | 0.06 [0–0.23] | 0.01 [0–0.41] | 2.6 | 0.25 [0–0.36] | 0.20 [0–0.37] | 2.6 | 0.12 [0–0.29] |
| Uncinate fasciculus | ||||||||||
| Left | 90 | 0.23 [0–0.46] | 55.6 | 0.05 [0–0.25] | 0.07 [0–0.43] | 20.0 | 0.24 [0–0.38] | 0.17 [0–0.45] | 51.1 | 0.11 [0–0.26] |
| Right | 87 | 0.20 [0–0.49] | 41.4 | 0.06 [0–0.25] | 0.07 [0–0.45] | 41.4 | 0.18 [0–0.32] | 0.13 [0–0.43] | 41.4 | 0.12 [0–0.28] |
| Sup. longitudinal fasciculus | ||||||||||
| Left | 75 | 0.21 [0–0.44] | 36.0 | 0.03 [0–0.26] | 0.02 [0–0.25] | 0.0 | 0.25 [0–0.43] | 0.23 [0–0.44] | 58.7 | 0.12 [0–0.31] |
| Right | 70 | 0.24 [0–0.46] | 38.6 | 0.02 [0–0.24] | 0.13 [0–0.52] | 25.7 | 0.15 [0–0.41] | 0.26 [0–0.51] | 62.9 | 0.11 [0–0.26] |
| Inf. longitudinal fasciculus | ||||||||||
| Left | 100 | 0.29 [0–0.50] | 57.0 | 0.05 [0–0.26] | 0.02 [0–0.31] | 0.0 | 0.24 [0–0.34] | 0.24 [0–0.48] | 62.0 | 0.09 [0–0.31] |
| Right | 100 | 0.23 [0–0.56] | 36.0 | 0.05 [0–0.22] | 0.05 [0–0.48] | 5.0 | 0.23 [0–0.41] | 0.22 [0–0.54] | 42.0 | 0.11 [0–0.28] |
| Inf. fronto-occipital fasciculus | ||||||||||
| Left | 158 | 0.27 [0–0.55] | 58.9 | 0.08 [0–0.34] | 0.11 [0–0.49] | 20.9 | 0.21 [0–0.41] | 0.25 [0–0.46] | 61.4 | 0.08 [0–0.29] |
| Right | 152 | 0.26 [0–0.49] | 54.6 | 0.07 [0–0.28] | 0.11 [0–0.64] | 22.4 | 0.23 [0–0.40] | 0.26 [0–0.50] | 69.1 | 0.10 [0–0.35] |
| Optic tract | ||||||||||
| Left | 70 | 0.20 [0–0.45] | 38.6 | 0.05 [0–0.38] | 0.13 [0–0.61] | 25.7 | 0.12 [0–0.40] | 0.13 [0–0.61] | 28.6 | 0.11 [0–0.40] |
| Right | 66 | 0.19 [0–0.44] | 10.6 | 0.09 [0–0.32] | 0.12 [0–0.65] | 19.7 | 0.14 [0–0.45] | 0.17 [0–0.70] | 25.8 | 0.10 [0–0.29] |