Table 5.
Correlation between tract-averaged diffusion parameters and their genetic contribution estimates
| FA vs a2FA
|
AD vs a2AD
|
RD vs a2RD
|
||||
|---|---|---|---|---|---|---|
| r | p | r | P | r | P | |
| Corpus callosum | ||||||
| rostrum, orbitofrontal | 0.68 | <.001 | −0.51 | <.001 | −0.58 | <.001 |
| genu, prefrontal | 0.53 | <.001 | −0.42 | <.001 | 0.05 | .63 |
| body, premotor | 0.71 | <.001 | −0.28 | .01 | 0.42 | <.001 |
| body, motor | 0.30 | .01 | −0.09 | .43 | 0.35 | <.005 |
| body, parietal | 0.74 | <.001 | 0.22 | .01 | 0.65 | <.001 |
| splenium, occipital | 0.78 | <.001 | 0.03 | .72 | −0.05 | .56 |
| tapetum, temporal | 0.43 | <.001 | 0.73 | <.001 | 0.51 | <.001 |
| Cortico-thalamic tract | ||||||
| prefrontal, left | 0.59 | <.001 | 0.73 | <.001 | 0.71 | <.001 |
| prefrontal, right | 0.33 | <.005 | 0.82 | <.001 | 0.75 | <.001 |
| premotor, left | 0.41 | <.001 | 0.44 | <.001 | 0.53 | <.001 |
| premotor, right | −0.03 | .82 | 0.37 | <.005 | 0.70 | <.001 |
| motor, left | 0.01 | .91 | 0.43 | <.001 | 0.66 | <.001 |
| motor, right | 0.30 | .01 | 0.35 | <.005 | 0.61 | <.001 |
| parietal, left | −0.25 | .04 | 0.60 | <.001 | 0.71 | <.001 |
| parietal, right | −0.03 | .81 | 0.43 | <.001 | 0.86 | <.001 |
| Corticofugal tract | ||||||
| prefrontal, left | 0.07 | .46 | 0.66 | <.001 | 0.68 | <.001 |
| prefrontal, right | 0.01 | .93 | 0.69 | <.001 | 0.72 | <.001 |
| premotor, left | 0.03 | .77 | 0.58 | <.001 | 0.65 | <.001 |
| premotor, right | −0.05 | .60 | 0.52 | <.001 | 0.73 | <.001 |
| motor, left | −0.13 | .15 | 0.20 | .03 | 0.55 | <.001 |
| motor, right | −0.35 | <.001 | 0.14 | .14 | 0.72 | <.001 |
| parietal, left | 0.09 | .31 | 0.38 | <.001 | 0.79 | <.001 |
| parietal, right | −0.33 | <.001 | 0.38 | <.001 | 0.89 | <.001 |
| Medial lemniscal | ||||||
| left | 0.69 | <.001 | 0.51 | <.005 | 0.63 | <.001 |
| right | 0.64 | <.001 | 0.31 | .05 | 0.44 | <.005 |
| Cingulum | ||||||
| cingulate gyrus, left | 0.54 | <.001 | 0.06 | .61 | 0.01 | .97 |
| cingulate gyrus, right | 0.12 | .29 | −0.43 | <.001 | 0.31 | .01 |
| hippocampal, left | 0.66 | <.001 | 0.02 | .81 | 0.75 | <.001 |
| hippocampal, right | 0.24 | .02 | −0.16 | .10 | 0.27 | .01 |
| Fornix | ||||||
| left | 0.38 | <.001 | 0.80 | <.001 | 0.72 | <.001 |
| right | 0.41 | <.001 | 0.59 | <.001 | −0.17 | .04 |
| Arcuate fasciculus | ||||||
| fronto-parietal, left | 0.64 | <.001 | 0.24 | .05 | −0.03 | .82 |
| fronto-parietal, right | 0.36 | <.005 | 0.22 | .09 | −0.07 | .59 |
| fronto-temporal, left | 0.56 | <.001 | 0.15 | .10 | −0.70 | .46 |
| fronto-temporal, right | 0.47 | <.001 | −0.58 | <.001 | −0.13 | .19 |
| temporo-parietal, left | 0.17 | .15 | −0.08 | .46 | −0.24 | .03 |
| temporo-parietal, right | −0.14 | .23 | −0.10 | .40 | 0.29 | .01 |
| Uncinate fasciculus | ||||||
| left | 0.45 | <.001 | 0.78 | <.001 | 0.76 | <.001 |
| right | 0.35 | <.005 | 0.55 | <.001 | 0.34 | <.005 |
| Sup. longitudinal fasciculus | ||||||
| left | 0.44 | <.001 | 0.16 | .17 | −0.05 | .68 |
| right | 0.28 | .02 | 0.22 | .07 | 0.11 | .36 |
| Inf. longitudinal fasciculus | ||||||
| left | 0.54 | <.001 | −0.30 | <.005 | −0.69 | <.001 |
| right | 0.66 | <.001 | 0.16 | .12 | −0.18 | .07 |
| Inf. fronto-occipital fasciculus | ||||||
| left | 0.60 | <.001 | 0.21 | .01 | 0.30 | <.001 |
| right | 0.32 | <.001 | 0.34 | <.001 | 0.31 | <.001 |
| Optic tract | ||||||
| left | −0.29 | .01 | 0.05 | .70 | 0.43 | <.001 |
| right | 0.13 | .31 | 0.24 | .06 | 0.57 | <.001 |