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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Nucl Med Biol. 2014 Dec 20;42(5):488–493. doi: 10.1016/j.nucmedbio.2014.12.008

Figure 2.

Figure 2

Blockade of [125I]iodo-ASEM accumulation in CD-1 mouse brain regions by injection of ondansetron (2 mg/kg, s.c.) and cytisine (0.5 mg/kg, s.c.) at 180 min time-point after the radiotracer injection. Data: mean %injected dose/g tissue ± SD (n = 3). Abbreviations: CB = cerebellum; Hipp = hippocampus; Ctx = cortex; Coll = superior and inferior colliculus. Neither drug significantly reduced [125I]iodo-ASEM accumulation in any of these regions (P > 0.05, ANOVA). The study demonstrates that [125I]iodo-ASEM is α7-nAChR selective in vivo versus the 5-HT3receptor and the main cerebral α4β2 -nAChR subtype.