Table 1.
Variable | Low Risk (n = 21) | APOE e4 (n = 24) | p* | Cohen’s d |
---|---|---|---|---|
MMSE | 29.29 (0.85)** | 29.21 (0.98) | 0.78 | 0.08 |
DRS-2 memory | 24.29 (0.96) | 24.04 (1.60) | 0.53 | 0.18 |
DRS-2 total | 141.05 (1.99) | 140.33 (3.60) | 0.41 | 0.24 |
RAVLT delayed recall | 9.90 (2.14) | 9.75 (2.92) | 0.84 | 0.06 |
RAVLT trials 1–5 | 49.33 (8.39) | 48.50 (8.17) | 0.74 | 0.10 |
fMRI task | ||||
Famous (% correct) | 93.97 (5.23) | 91.39 (7.54) | 0.19 | 0.39 |
Non-famous (% correct) | 95.87 (5.76) | 97.78 (3.63) | 0.20 | −0.40 |
d′ | 3.29 (0.64) | 3.32 (0.62) | 0.85 | −0.06 |
Famous (RT, msec) | 1236 (180) | 1249 (151) | 0.81 | −0.07 |
Non-famous (RT, msec) | 1622 (354) | 1578 (358) | 0.68 | 0.13 |
IIV famous (RT) | 351 (90) | 371 (131) | 0.57 | −0.17 |
IIV non-famous (RT) | 347 (101) | 330 (94) | 0.56 | 0.18 |
Hippocampal volume (% ICV) | 0.47 (0.06) | 0.46 (0.07) | 0.63 | 0.14 |
MMSE = Mini Mental State Examination; DRS-2 = Dementia Rating Scale-2; RAVLT = Rey Auditory Verbal Learning Test; RT = reaction time; IIV= intraindividual variability based on the average standard deviation of RTs for correct responses; % ICV = percent intracranial volume.
p-Values derived from Student t-test, except for gender (Fischer’s exact test).
Mean (standard deviation).