Table 2.
Coefficients from linear mixed effects analysis of neuropsychological test scores, fMRI task performance, and hippocampal volume.
| Variable | Intercept (baseline)
|
Slope (time)
|
||
|---|---|---|---|---|
| Low Riska | APOE ε4 vs. Low Riskb | Low Riskc | APOE ε4 vs. Low Riskd | |
| MMSE | 29.35 (0.18) | 0.014 (0.246) | 0.004 (.007) | −0.014 (.009) |
| DRS-2 memory | 24.30 (0.27) | −0.597 (0.367) | 0.008 (.008) | −0.019 (.011) |
| DRS-2 total | 140.19 (0.58) | −0.717 (0.790) | 0.007 (.016) | −0.019 (.022) |
| RAVLT delayed recall | 9.63 (0.56) | −0.397 (0.770) | 0.006 (.011) | −0.036 (.015) |
| RAVLT trials 1–5 | 48.84 (1.71) | −1.515 (2.339) | −0.005 (.032) | −0.028 (.044) |
| fMRI task | ||||
| Famous (% correct) | 94.46 (1.27) | −2.479 (1.738) | −0.099 (0.054) | 0.026 (0.074) |
| Non-famous (% correct) | 96.91 (1.09) | 1.456 (1.498) | −0.113 (0.071) | −0.030 (0.097) |
| d′ | 3.38 (0.12) | −0.011 (0.162) | −0.007 (0.005) | −0.003 (0.006) |
| Famous (RT, msec) | 1248.0 (36.0) | −0.893 (49.339) | −1.034 (0.757) | 1.688 (1.046) |
| Non-famous (RT, msec) | 1628.1 (74.1) | −46.960 (101.430) | −3.425 (1.675) | 3.997 (2.304) |
| IIV famous (RT, msec) | 353.4 (23.0) | 10.622 (31.475) | −0.237 (0.408) | 0.532 (0.564) |
| IIV non-famous (RT, msec) | 338.3 (21.4) | −5.952 (29.308) | −0.438 (0.593) | 1.394 (0.817) |
| Hippocampal volume (% ICV) | 0.47 (0.01) | −0.0100 (0.0203) | −0.0001 (0.0001) | −0.0003 (0.0001) |
Bolded values are statistically significant at p < 0.05.
MMSE=MiniMental State Examination; DRS-2=Dementia Rating Scale-2; RAVLT=Rey Auditory Verbal Learning Test; RT=reaction time; IIV=intraindivual variability based on the average standard deviation of RTs for correct responses; % ICV = percent intracranial volume.
Predicted mean intercept (baseline) value of each dependent variable for the Low Risk group. All values are statistically significant from 0.
Predicted difference between mean intercept (baseline) values for the Low Risk group and the APOE ε4 group.
Predicted average monthly rate of change (slope) for the Low Risk group.
Predicted difference in the average monthly rate of change (slope) between the Low Risk group and the APOE ε4 group. Standard errors of coefficients are in parentheses.