Table 4.

Hierarchical Regression Analysis for Clinical Trial Attitudes (n = 251)

Models	df†	F†	ΔR2 †	p-value
1. Demographics	3	4.11	.048	.007
2. Disease Severity	11	1.33	.055	.211
3. Healthcare Experience Ratings	5	2.21	.041	.054
4. Patient Trust	2	0.48	.004	.619
5. Patient Engagement in Self-Care	2	5.28	.038	.006
6. Prior Trial Participation	1	4.46	.016	.036
Total R2			0.20

^†df = Model degrees of freedom; F = F-statistic for the model; Δ R² = proportion of variability in the dependent variable attributed to the model

Model 1 - Demographics: Patient Age, Education

Model 2 – Model 1 + Disease Severity (Perceived health status, ED utilization, Inpatient Utilization, Daily Chronic Pain)

Model 3 – Model 2 + Healthcare Experience Ratings (Provider Communication Ratings, Provider Partnership Ratings, Perceived racial/ethnic discrimination, perceived disease-based discrimination)

Model 4 – Model 3 + Patient Trust (Trust in Medical Professionals, Distrust in Medical Institutions)

Model 5 – Model 4 + Patient Engagement in Self-Care (SCD Self-Care Score, SCD Self-Efficacy)

Model 6 – Model 5 + Prior Trial Participation (Previous Participation in a clinical trial [yes vs. no])