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. Author manuscript; available in PMC: 2016 Apr 10.
Published in final edited form as: Exp Cell Res. 2015 Feb 13;333(1):39–48. doi: 10.1016/j.yexcr.2015.02.002

Figure 4. PiT-1 point mutations impair sodium-dependent Pi uptake in VSMCs.

Figure 4

Sodium-dependent Pi uptake was quantified over a range of Pi concentrations in VSMCs expressing vector control, PiT-1 WT, PiT-1-E74K, PiT-1-S132A, or PiT-1-S623A. VSMC Pi uptake was measured over 20 minutes and normalized to time and VSMC protein content. Dashed connecting lines signify PiT-1 point mutation constructs. Data presented as mean ± S.D., n = 3 for all data points. Statistically significant differences between Vector Control and each PiT-1 construct at the same Pi concentration are indicated by * = P<0.05 as measured by One-way ANOVA post-hoc Tukey analysis.