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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Leukemia. 2014 Oct 6;29(4):918–926. doi: 10.1038/leu.2014.293

Figure 2. R848 induces terminal differentiation in AML cell lines.

Figure 2

(A) R848 slows the growth rate of AML cell lines. Equal numbers of HL60, OCI-AML3, THP1, HCT116 and 293T cell lines were treated with R848 for at least 72 hours and monitored by MTT assay for proliferation. MTT signal was normalized to untreated controls. * indicates p< 0.05 ** indicates p<0.01. (B) R848 inhibits colony formation of AML cell lines. HL60, OCI-AML3, THP1 and normal cord blood cells were treated with R848. After at least 72 hours of R848 treatment, the drug was washed away and an equal number of viable cells were cultured in a semisolid soft agar medium for 7 days. ** indicates p<0.01.