Table 1.
The mean value of different parameters in control (C), sensitized (S), sensitized pretreated with thymoquinone (S+TQ), sensitized pretreated with selective A2A antagonist (ZM241385) and selective A2B antagonist (MRS1706) (S+Anta A2A and S+Anta A2B), sensitized groups pretreated with selective A2A antagonist and thymoquinone (S+Anta A2A+TQ) and selective A2B antagonist and thymoquinone (S+Anta A2B+TQ). Statistical differences between pretreated groups vs S+TQ group: NS: non significant differences, +; P<0.05, ++; P<0.01, +++; P<0.001
The mean value of | C | S | S+TQ | S+Anta A2A | S+Anta A2B | S+Anta A2A+ TQ | S+Anta A2B+ TQ |
---|---|---|---|---|---|---|---|
EC50 | 5.31±0.71 | 1.50±0.36 | 2.35±0.14 | 1.38±0.24 | 3.10±0.54 | 2.18±0.51 | 3.43±0.64 |
++ | NS | NS | NS | ||||
OA | 4.85±3.18 | 62.88±9.12 | 22.49±4.42 | 64.72±9.01 | 44.49±13.95 | 24.27±6.32 | 21.67±2.95 |
++ | NS | NS | NS | ||||
Contractility | 0.58±0.04 | 1.63±0.08 | 1.28±0.19 | 1.84±0.21 | 1.27±0.05 | 1.41±0.19 | 1.23±0.23 |
NS | NS | NS | NS | ||||
LLF WBC | 2580±180.02 | 9421.43±1609.1 | 6073.14±879.86 | 9896.43±288.8 | 5950±1035.7 | 7923.57±523.79 | 4825.0±552.59 |
++ | Ns | Ns | Ns | ||||
LLF eosinophil | 9.47±1.34 | 45.73±2.23 | 15.4±1.14 | 52.47±1.83 | 21±0.55 | 30.93±0.82 | 19.4±2.37 |
+++ | +++ | +++ | Ns | ||||
LLF monocyte | 5.33±0.53 | 0.86±0.32 | 3.20±0.24 | 0.73±0.25s | 5.06±0.38 | 1.33±0.28 | 4.0±0.36 |
+++ | +++ | +++ | Ns | ||||
LLF lymphocyte | 72.467.2±3.02 | 42.93±2.02 | 63.67±3.19 | 33.87±1.99 | 70.13±1.37 | 61.87±1.17 | 66.53±2.46 |
+++ | Ns | Ns | Ns | ||||
LLF neutrophil | 5.60±0.73 | 0.53±0.19 | 4.93±0.54 | 0.80±0.24 | 5.87±0.50 | 2.40±0.47 | 6.06±0.46 |
+++ | Ns | ++ | Ns | ||||
LLF basophil | 3.60±0.62 | 4.73±0.50 | 2.80±0.78 | 4.27±0.59 | 2.47±0.53 | 3.0±0.64 | 3.67±0.71 |
Ns | Ns | Ns | Ns |