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. Author manuscript; available in PMC: 2015 Apr 7.
Published in final edited form as: Nat Rev Mol Cell Biol. 2013 May;14(5):283–296. doi: 10.1038/nrm3565

Figure 4. TFEB regulates cellular clearance.

Figure 4

TFEB controls lysosomal biogenesis by regulating the level of lysosomal enzymes, lysosomal acidification and the number of lysosomes. TFEB also controls autophagy by regulating the number of autophagosomes and the fusion between autophagosomes and lysosomes. Finally. TFEB regulates docking and fusion of lysosomes to the plasma membrane in the process of lysosomal exocytosis. The concerted action of these three processes leads to cellular clearance. TFEB