Table 4.

Relationship between the efficacy and injection site reactions

	With ISR (n = 37)	Without ISR (n = 17)
	N (%)	N (%)	P-value
Response
Complete response (CR)	0 (0.0)	0 (0.0)
Partial response (PR)	10 (27.0)	0 (0.0)
Stable disease (SD)	20 (54.1)	8 (47.1)
Progressive disease (PD)	7 (18.9)	7 (41.2)
Not evaluable (NE)	0 (0.0)	2 (11.8)
Overall survival
Median survival (95 % CI)	14.8 months (9.8, 18.4)	5.7 months (4.6, 8.6)	0.002 (H-F), <0.001 (log-rank)

CI confidence interval, ISR injection site reaction