Fig. 4.

PBI-05204 markedly inhibited tumor proliferation in the Panc-1 orthotopic model as evidenced by a reduction of Ki-67 staining (A) and in human pancreatic cancer cells (B) by induction of apoptosis (C). A, a). Vehicle control; b) PBI-05204 (10 mg/kg); c) PBI-05204 (20 mg/kg). B. Proliferation of Panc-1 and CaPan-II cells treated with PBI-05204 for 72 h measured by MTT assay. C. PI staining of Panc-1 cells treated with PBI-05204 for 48 h. * P < 0.05 PBI-05204 treated versus vehicle treated group