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Oral administration of PBI-05204 down regulated the PI3kinase/mTOR pathway proteins in human Panc-1 orthotopic tumors. Tumor sections were obtained by the end of 6 weeks treatment and stained with antibodies raised against pAkt (Ser473), pS6 (Ser 235/236) and p4EBP1 (Thr37/46) proteins and counter stained with hematoxylin
