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Mean plasma concentration-time profiles of BI 831266 on a day 1 and b day 15 of cycle 1 after 24-h infusion of 4, 8, 16, 32, 64 and 130 mg BI 831266. Footnote: Concentration-time data could only be evaluated for 2 out of 3 patients in the 8 mg cohort on day 15, therefore standard deviation values could not be calculated
