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. 2015 Apr 6;212(4):469–480. doi: 10.1084/jem.20132423

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© 2015 Gao et al.

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Figure 4. — Mice with deletion of CD95L in peripheral myeloid cells (CD95L^f/f;LysMcre chimera mice) are resistant to MPTP neurotoxicity. (A) Scheme of CD95L^f/f;LysMcre BM chimera mice. The heads of BM recipient mice were covered with a lead cap during irradiation to avoid irradiation-induced monocyte infiltration. (B) Representative FACS dot plots of CD45.1- and CD45.2-stained blood samples from CD95L^{f/f;LysMcre±} BM chimera mice. (C) BM reconstitution level of chimera mice before the injection of saline or MPTP. Data are presented as mean ± SEM; n = 6–7. (D) Quantification of total TH⁺ DNs in the SNpc at day 6 after last administration of saline or MPTP to CD95L^{f/f;LysMcre±} BM chimera mice. Data are presented as dot plot with median; n = 6–7. (C and D) ANOVA followed by Newman–Keuls post-hoc test: *, P < 0.05; ***, P < 0.001.