Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 6;212(4):513–524. doi: 10.1084/jem.20141671

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Cheng et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — Basophils regulate eosinophil accumulation after vaccination and in models of human atopic dermatitis. (A) Basophil-deficient (Basoph8 × DTA) or -sufficient mice (Basoph8) were immunized with either DNP-OVA or OVA in alum and challenged with topical DNFB 10 d later. Eosinophil accumulation was examined on day 3 after challenge. Results were pooled from three separate experiments with at least eight mice per group using littermates. (B) Basophil-sufficient (Basoph8) and -deficient (Basoph8 × DTA) mice were sensitized with anti-TNP IgE through intravenous injection and challenged 1 d later by tape stripping and epicutaneous application of TNP-OVA. Eosinophil accumulation was then examined 3 d after antigen challenge. Results were pooled from two separate experiments with at least six mice per group. (A and B) Horizontal bars denote mean. P-values were determined using ANOVA: ***, P < 0.001.