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. 2015 Mar 16;36(4):473–482. doi: 10.1038/aps.2014.155

Figure 5.

Figure 5

Effects of EGCG on the PI3K/Akt/Smad signaling pathway in LX-2 cells and BDL rat livers. (A) LX-2 cells were treated with EGCG, LY294002 or both for 24 h, the mRNA expression of COL1A1 and TGF-β1 were detected by real-time PCR, and (B) the expression of liver fibrogenic protein and members of the PI3K/Akt/Smad signaling pathway were detected by Western blotting. (C) The protein expression of members of the PI3K/Akt and TGF-β/Smad signaling pathways in BDL rat livers, and the quantification of the whole group (n=10). bP<0.05 vs the sham group. eP<0.05 vs the BDL group.