Figure 4.

Effects of JNK or p38 MAPK inhibitor on CRP-induced JNK phosphorylation, p38 MAPK phosphorylation, NF-κB p65 phosphorylation and RAGE expression in HCAECs. (A) Western blot analysis of JNK phosphorylation and p38 MAPK phosphorylation in HCAECs treated with vehicle, CRP, JNK inhibitor (SP600125), p38 MAPK inhibitor (SB203580), JNK inhibitor with CRP or p38 MAPK with CRP. (B) RAGE expression in HCAECs. Data are represented as the mean±SEM (n=3–6). ^bP<0.05, ^cP<0.01 vs vehicle. ^eP<0.05 vs CRP.