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Recombinant IL-37b promoted CD4+ but not CD8+ T cell proliferation in vitro. Isolated CD4+ or CD8+ T cells from lymphocytes were stimulated with an anti-CD3 antibody for 72 h, with or without the addition of recombinant IL-37b. Cell size measured by FSC, the CFSE proliferation profile, and the expression of CD25 and CD69 were analyzed by flow cytometry. The data are representative of four independent experiments.
