Table 4. EC50 and Emax values for SNP in the absence and presence of inhibitors in aortas from saline and nicotine treated rats. Data are expressed as mean±SEM. n=3–8. bP<0.05, cP<0.01 vs Sal. EC50, drug concentration required to induce 50% relaxation; Emax, the maximum relaxant responses (SNP at 10−4 mol/L).
| Control |
Treatment |
||||
|---|---|---|---|---|---|
| EC50 (nmol/L) | Emax (%) | EC50 (nmol/L) | Emax (%) | ||
| Sal (F−E−) | ODQ | 32.50±8.61 | 92.91±1.89 | 2863.50±895.01 | 10.96±2.25 |
| PKG inhibitor | 12.80±2.25 | 99.38±0.31 | 43.33±3.33 | 101.93±1.92 | |
| Nic (F−E−) | ODQ | 6.00±0.68b | 101.03±0.30c | 2625.00±993.69 | 19.45±3.74 |
| PKG inhibitor | 6.00±1.27b | 104.05±1.73b | 27.50±7.50 | 99.28±3.62 | |