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An LRN case showing malignant transformation. a A hypoechoic nodule 13 mm in diameter was detected by US (arrows). b Biopsy specimen showed minimal atypia. Diagnosis was large regenerative nodule (bar 50 μm). c Size and US findings showed no change for 26 months (arrows). d At 32 months, the nodule had enlarged to 23 mm (arrows). e Histological specimen from rebiopsy showed definite increased cellularity, and diagnosis was well differentiated HCC (bar 50 μm)
