Figure 5.

Perturbing self-assembly. The upper right and left panels show deviations from the target configuration when the self-assembly is confounded by changing the concentration of (or sensitivity to) exogenous gradients. The first intervention illustrates a failure of migration and differentiation that results from non-specific suppression of exogenous signals, while selectively increasing the vertical gradient produces compression along the corresponding direction. More exotic forms of dysmorphogenesis result when decreasing the intracellular (intrinsic: lower left panel) and extracellular (extrinsic: lower right panels) receptor sensitivities. (Online version in colour.)