Table 1.
Summary of expression changes of 561 proteins identified in Control and PAH-BRMP2 PASMCs, in response to elevation in ET-1, as detected by label-free LC/MS quantitation.
| Fold change | Protein Numbers | |||
|---|---|---|---|---|
| Control(+) ET-1 vs. Control(–) ET-1 |
PAH (+) ET-1 vs. PAH (–) ET-1 |
PAH (–) ET-1 vs. Control(–) ET-1 |
PAH (+) ET-1 vs. Control(+) ET-1 |
|
| Up-regulated(>2) | 60 | 390 | 30 | 137 |
| Up-regulated (2 to1.33) | 412 | 162 | 180 | 312 |
| Down-regulated (−2 to −1.33) | 0 | 0 | 45 | 10 |
| Down-regulated (<−2) | 0 | 0 | 16 | 10 |
| No change (within ±1.33) | 89 | 9 | 290 | 92 |