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. 2015 Mar 26;34(1):27. doi: 10.1186/s13046-015-0142-9

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© Cheng et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Up-miR-184 reduced the invasiveness and growth of glioma cells. A. Wound healing assay shows that the migration of U87 and U251 cells transfected with miR-184 mimics or inhibitor. The overexpression of miR-184 inhibited the wound closure speed of U87 and U251 cells compared with the Negative group or inhibitor group. B. Transwell assay shows the invasion of U87 and U251 cells transfected with miR-184 mimics or inhibitor. which revealed that the numbers of invasive cells were significantly reduced compared with the Negative group or inhibitor group. Each bar represents the mean values from three independent experiments. The invaded cells were counted from 6 random fields. C. shows the cell survival, which was determined by the CCK-8 assay. Cell proliferation was dramatically decreased in U251 and U87 cells after transfection with miR-184. Data are shown as mean + s.d. (n = 3); *indicates P-value <0.05, **indicates P-value <0.01.