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. 2015 Apr 1;15:42. doi: 10.1186/s12876-015-0269-3

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© Nozaki et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Analysis of factors associated with the pathogenesis of NAFLD: body weight, systemic insulin resistance and liver NO metabolites. (A) No significant difference was observed between iNOS+/+/HFD and iNOS−/−/HFD mice throughout the experimental period. (B, C and D) Fasting glucose and fasting insulin levels were significantly higher in iNOS+/+/HFD mice than in iNOS−/−/HFD mice at 10 weeks. HOMA-IR levels were significantly higher in iNOS+/+/HFD mice than in iNOS−/−/HFD mice at both 10 and 48 weeks. (E) Decreases in blood glucose were significantly greater in iNOS+/+/HFD mice than in iNOS−/−/HFD mice at 20, 60, 80 and 100 minutes after insulin injection. (F) The liver nitrate/nitrite concentrations in iNOS+/+/HFD mice were higher at 48 weeks than at 10 weeks; and other groups showed little concentrations at both 10 and 48 weeks. Liver nitrate/nitrite concentrations were significantly higher in iNOS+/+/HFD mice than in iNOS−/−/HFD mice at both 10 and 48 weeks. (Data are expressed as the mean ± SEM. * p < 0.05 and ** p < 0.01, represents significant difference between iNOS+/+/HFD mice and iNOS−/−/HFD mice).