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. 2015 Apr 1;29(7):760–771. doi: 10.1101/gad.258863.115

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© 2015 Gao et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — Trans-splicing of mod(mdg4) is facilitated by two intronic RNA motifs. Highly conserved TSA and TSB RNAs located in the last 5′ intron are critical for trans-splicing of mod(mdg4). TSA RNA is sufficient to promote trans-splicing in Drosophila, which binds U1 snRNP through strong base-pairing between its highly conserved 13-nt TSA core motif and the 5′ end of U1 snRNA. TSB RNA forms a highly conserved secondary structure and enhances the trans-splicing activity of mod(mdg4). Including the formation of a Y-structured intermediate, the two-step chemical reactions of trans-splicing are indicated.