Figure 4.

Endogenous FGF2 mediates the cardiac hypertrophic response in the peri‐infarct area after cardiac ischemia‐reperfusion injury. (A) Representative images of wheat germ agglutinin staining in the peri‐infarct area of Fgf2^−/− and wild‐type mice at multiple time points after IR injury or sham treatment (green – wheat germ agglutinin, blue – DAPI). (B) Fgf2^−/− mice have decreased cardiomyocyte cross‐sectional area in the peri‐infarct area at 3 and 7 days after IR injury compared to wild‐type controls. (C) There is no significant difference in cardiomyocyte cross‐sectional area in the remote myocardium in any treatment group. n = 3–8, *P < 0.05 versus wild type, ^#P < 0.05 versus sham, ⁺P < 0.05 versus 1 day time point.