Table 3.
Effect of pH alteration using PPIs on gastric fluid contents
| Mean ± SEM No PPI | Mean ± SEM PPI | P‐value (mean) P‐value (variance) | |
|---|---|---|---|
| Pepsin concentration | 55.1 ± 15.6 N = 8 |
20.2 ± 9.78 N = 7 |
0.089 0.218 |
| Gastricsin concentration | 773 ± 415 N = 8 |
607 ± 344 N = 5 |
0.546 0.065 |
| Trypsin concentration | 5.26 ± 3.81 N = 25 |
29.9 ± 9.80 N = 17 |
<0.0001 0.0561 |
| Bile concentration | 134 ± 38.3 N = 24 |
1500 ± 683 N = 17 |
0.140 0.051 |
| Viscosity | 1.22 ± 0.0641 N = 10 |
1.73 ± 0.354 N = 8 |
0.202 |
| Relative viscosity | 1.95 ± 0.310 N = 10 |
4.42 ± 1.71 N = 8 |
0.202 |
| pH | 3.19 ± 0.359 N = 39 |
5.19 ± 0.505 N = 25 |
0.007 |
| Live bacteria | 2.68×107 ± 1.14×107 N = 9 |
1.67×107 ± 4.56×106 N = 5 |
0.862 0.088 |
| Dead bacteria | 7.68×107 ± 3.80×107 N = 9 |
1.83×107 ± 6.34×106 N = 5 |
0.119 0.792 |
| Total particles | 6.91×108 ± 2.72×108 N = 11 |
2.54×108 ± 6.04×107 N = 5 |
0.165 0.227 |
Samples from patients on PPIs that was less than 3.0, or from patients not taking PPIs that was greater than 3.0 were excluded (21 samples excluded for all tests except pH t‐test). The P‐value for both the mean and the variance was determined using an unpaired t‐test and an F‐test respectively. A P‐value of less than 0.05 was considered significant.