Table 1.
Susceptibility genes for Brugada syndrome
| Gene | Type of BrS | Detection rate of mutation (%) | |
|---|---|---|---|
| The cardiac voltage‐gated sodium channel and associated proteins | SCN5A | BrS 1 | 11–28 |
| GPD1‐L | BrS 2 | <1 | |
| SCN1B | BrS 5 | <1 | |
| SCN3B | BrS 7 | <1 | |
| MOG1 | BrS 11 | <1 | |
| SLMAP | BrS 15 | <1 | |
| SCN2B | BrS 17 | <1 | |
| Potassium channels and associated proteins | KCNH2 | BrS 8 | <1 |
| KCNE3 | BrS 6 | <1 | |
| KCNE5 | BrS 12 | <1 | |
| KCNJ8 | BrS 9 | <1 | |
| KCND3 | BrS 13 | <1 | |
| Calcium channel and associated proteins | CACNA1c | BrS 3 | 3–4 |
| CACNB2b | BrS 4 | 2–3 | |
| CACNA2D1 | BrS 10 | <1 | |
| Nonselective cation channels | TRMP4 | BrS 16 | <6 |
| Hyperpolarization activated cyclic nucleotide‐gated channels | HCN4 | BrS 14 | <1 |
BrS, Brugada syndrome.