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. 2015 Jan 27;3(1):e12272. doi: 10.14814/phy2.12272

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — HSPG2^−/−‐Tg aortas have a reduced relaxation in response to ACh or SNP. The aortic rings were precontracted with 1 µmol/L phenylephrine (PE), and increasing concentrations of (A) acetylcholine (ACh) or (B) sodium nitroprusside (SNP) were added. The degree of relaxation is expressed as the percent relaxation of the PE‐induced tone (The bars indicate the mean ± SEM, n = 5–10).