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. Author manuscript; available in PMC: 2015 Apr 7.
Published in final edited form as: Annu Rev Chem Biomol Eng. 2014;5:281–299. doi: 10.1146/annurev-chembioeng-060713-040447

Figure 14.

Figure 14

(a) Illustration of the combined modality therapy using paclitaxel (TAX)-loaded filomicelles (green) with localized radiotherapy (yellow). Penetration of drug-loaded nanocarriers (DLN) to the brain tumor from the blood circulation is prevented by the tumor blood-brain barrier (T-BBB). Upon radiation, the permeability of the T-BBB is altered and allows extravasation of the DLN into the tumor tissue. (b) Bioluminescence images of intracranial tumors in mice treated with radiation therapy (RT) and with a combination of RT and DLN. (c) Kaplan-Meier survival curves for mice treated with stereotactic RT (sRT) and with a combination of sRT and a high dose of DLN (hiDLN). Adapted from Reference 80.